Methods in Electron Microscopy

Laboratory of Structural and Electron Microscopy, Institute for Structural Biology , Grenoble, France

Last updated : July 7, 2008

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Objectives

Our laboratory is interested in determining the structure of biological molecular complexes to reveal the molecular interactions and their biological implications. We employ cryo-electron microscopy and 3D image reconstruction to obtain medium resolution maps that we combine with the X-ray crystallography atomic structures of the component molecules. The development, validation and application of novel computational methods plays a key role in our research.

Within the laboratory, the Methods in Electron Microscopy (MEM) group aims at providing researchers (both expert and novice) with efficient and user-friendly tools for structure determination and interpretation. The main softwares developed in our group are listed below, with links to the specific page for each software (with Downloading Information, User's Manual, ...).

Softwares available :

	Un peu de tout	Suites of programs for MX, EM, and combined use
	RIco(L)	Reconstruction with Icosahedral Symmetry
	URO(X)	Fitting atomic models into Electron Microscopy reconstructions
	AMoRe(S)	Interactive molecular replacement